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Antibiotic Discovery and Development 2012

热度 1已有 449 次阅读2012-9-19 13:37 |个人分类:书籍介绍|系统分类:精品转载| 2012

Antibiotic Discovery and Development 2012

Thomas J. Dougherty  Michael J. Pucci
Editors

ISBN 978-1-4614-1399-8 e-ISBN 978-1-4614-1400-1
DOI 10.1007/978-1-4614-1400-1
Springer New York Dordrecht Heidelberg London
Library of Congress Control Number: 2011941801
© Springer Science+Business Media, LLC 2012
Contents

VOLUME I

Part I Introductory History of Antimicrobial Drugs
1 The Early History of Antibiotic Discovery: Empiricism Ruled .. 3
Richard J. White
2 Rational Approaches to Antibacterial Discoveryre-Genomic Directed and Phenotypic Screening .. 33
Lynn L. Silver

Part II Marketed Major Classes of Compounds
3 Beta-Lactam Antibiotics  79
Malcolm G.P. Page
4 Review of the Quinolone Family ... 119
George A. Jacoby and David C. Hooper
5 Tetracyclines ... 147
Patricia A. Bradford and C. Hal Jones
6 Macrolides and Ketolides .. 181
Ze-Qi Xu, Michael T. Flavin, and David A. Eiznhamer
7 Aminoglycosides . 229
Eliana S. Armstrong, Corwin F. Kostrub, Robert T. Cass, Heinz E. Moser, Alisa W. Serio, and George H. Miller
8 Oxazolidinone Antibacterial Agents  271
Michael R. Barbachyn
9 Glycopeptides and Lipoglycopeptides .. 301
F.F. Arhin, A. Belley, A. Rafai Far, D. Lehoux, G. Moeck, and T.R. Parr Jr.

Part III The Rise of Antibiotic Resistance/Resistance Mechanisms to Major Classes
10 Efflux-Mediated Antimicrobial Resistance .. 349
Keith Poole
11 Structural Mechanisms of b-Lactam Antibiotic Resistance in Penicillin-Binding Proteins ... 397
Robert A. Nicholas and Christopher Davies
12 Evolution of b-Lactamases: Past, Present, and Future .. 427
Karen Bush
13 Inducible Resistance to Macrolide Antibiotics  455
Sai Lakshmi Subramanian, Haripriya Ramu, and Alexander S. Mankin
14 Fluoroquinolone Resistance: Mechanisms,
Restrictive Dosing, and Anti-Mutant Screening Strategies for New Compounds  485
Karl Drlica, Xilin Zhao, Muhammad Malik, Tal Salz, and Robert Kerns
15 Glycopeptide Resistance  515
Bruno Pichon and Patrice Courvalin
16 Acquired Tetracycline Resistance Genes . 543
Marilyn C. Roberts

Part IV Clinical Issues of Resistance: 揥orst Offenders?
List of Problematic Microbes Gram-positives
17 Evolution of Molecular Techniques for the Characterization of MRSA Clones . 571
Duarte C. Oliveira, Herm韓ia de Lencastre,
and Alexander Tomasz
18 Mechanisms of Penicillin Resistance in Streptococcus pneumoniae: Targets, Gene Transfer and Mutations. 593
Regine Hakenbeck, Dalia Denapaite, and Patrick Maurer
19 Clinical Aspects of Multi-Drug Resistant Enterococci ... 617
German A. Contreras and Cesar A. Arias

Part V Gram-negatives
20 Clinical Issues of Resistance: Problematic Microbes:
Enterobacteriaceae. 651
David F. Brice, Juli A. Torres, Jos?D. Tafur, John P. Quinn, and Mar V. Villegas
21 Pseudomonas aeruginosa: A Persistent Pathogen in Cystic Fibrosis and Hospital-Associated Infections ... 679
Kristen N. Schurek, Elena B.M. Breidenstein, and Robert E.W. Hancock

Part VI Mycobacteria
22 Drug Resistant and Persistent Tuberculosis: Mechanisms and Drug Development 719
Ying Zhang

VOLUME II

Part VII Antibiotic Discovery

23 Resistance Trends and Susceptibility Profiles in the US Among Prevalent Clinical Pathogens: Lessons from Surveillance . 753
Chris Pillar and Dan Sahm
24 Chemical Properties of Antimicrobials and Their Uniqueness  793
Mark J. Macielag
25 Natural Products in the 21st Century .. 821
Sheo B. Singh
26 Permeability of Bacteria to Antibacterial Agents ... 849
Wright W. Nichols
27 Novel Antibacterial Targets/Identifi cation of New Targets by Comparative Genomics  881
Sarah M. McLeod, Thomas J. Dougherty, and Michael J. Pucci
28 Cell-Based Screening in Antibacterial Discovery ... 901
Scott D. Mills and Thomas J. Dougherty
29 Enzyme-Based Screens in HTS . 931
David E. Ehmann and Stewart L. Fisher
30 Antibacterial Inhibitors of the Essential Cell Division Protein FtsZ . 957
Lloyd G. Czaplewski, Neil R. Stokes, Steve Ruston, and David J. Haydon
31 Structure-Guided Discovery of New Antimicrobial Agents ... 969
Molly B. Schmid
32 NMR in Infection Research ... 985
Jun Hu and Gunther Kern
33 A Review of Animal Models Used for Antibiotic Evaluation . 1009
Andrea Marra
34 In Vivo Pharmacodynamic Modeling for Drug Discovery . 1035
Jared L. Crandon and David P. Nicolau
35 Applications of Pharmacokinetic/Pharmacodynamic Models for the Development of Antimicrobial Agents ... 1055
April Barbour and Hartmut Derendorf

Part VIII Antibiotic Drug Development
36 Antibiotic Drug Development: Moving Forward into the Clinic . 1071
Jane E. Ambler and Greg G. Stone

Part IX The Economics and Incentives of Antibiotic Drug Discovery
37 Stimulating Antibacterial Research and Development: Sense and Sensibility?  1103
Steven J. Projan

Index  1107